Objectives: Hyperglycosylated Human chorionic gonadotropin (hCG) is a variant of hCG. In addition, it has a different oligosaccharide structure compared to the regular hCG and promotes the invasion and differentiation of peripheral cytotrophoblast. This study aimed to measure hyperglycosylated hCG as a predictor in the diagnosis of placenta accreta. Materials and Methods: In general, 90 pregnant women were involved in this case-control study among which, 30 ladies (control group) were pregnant within the gestational age of ≥ 36 weeks with at least one previous caesarean section and a normal sited placenta in transabdominal ultrasound (TAU). The other 60 pregnant women (case group) were within a gestational age of ≥ 36 weeks at least, one previous caesarean section and placenta previa with or without signs of placenta accreta in TAU. Hyperglycosylated hCG and total hCG were measured in each group and the results of the surgery were followed up. Results: Hyperglycosylated hCG showed higher serum levels in patients with placenta accreta compared to those with placenta previa and control women. Hyperglycosylated hCG with an optimal cut point of (3) IU/L predicted placenta accreta in pregnant women with 90% specificity, 76. 7% sensitivity, and 81. 1% accuracy. Conclusions: The high specificity of the above approach makes it a good diagnostic tool (as a single test) for confirming placenta accreta in clinical settings. When this test is added to our established workup, its high positive predictive value makes it a suitable method within the algorithm of accreta confirmation when there is a high suspicion or insufficient evidence to the diagnosis of placenta accreta.

Introduction: Considering the high incidence of preterm labor and its known complications, and that Human myometrium contains receptors for Human chronic gonadotropin (hCG) and that hCG can inhibit myometrial contractions on vitro, made me study treating effects of hCG on preterm labor. This clinical trial study was carried out to compare the effect of hCG, and magnesium sulfate (mgso4) on prevention of preterm laborMaterials and methods: The study group included 101 women at weeks 22-35 of the gestation with intact membranes and cervical dilatation less than 4cm in preterm labor in referrals of obstetric - clinics in Khorramabad city during the years 2001- 2003.The case and control groups were treated with hCG protocol of the dosage consisted of one single dose of hCG 5000 1v and 10000 units of hCG in 500 dextrose as a drip of 20 drops per minute. Treatment continued until preterm labor arrested and then complications of mother and fetus were recorded.On condition of a successful cease of labor, the patients were discharged and followed uptill deliven time.Findings: Both groups were similar to each other regarding maternal age, gravity, and gestational age.Mean delay of labor was 22/68 days after administration of hCG and 24/27 days for (mgs04) that was not significant. The number of newborns that admitted in NICU were 9 (18%) for hCG and were 9 (17/8%) for magso4.Mean weight at labor was 233gr and 2287gr for hCG and mgso4.The complaint rate was 100% and 0% for magnesium sulfate and hCG groups respectively (P<0/000 1).Conclusion: since both drugs are alike regarding their effect on birth time, weight and delay of labor and furthermore, hCG exhibits potent tocolysis without fetal side effects. So it is recommended hCG to be used instead of mgso4 to prevent preterm labor.

Introduction: The most frequent physical finding in infertile men is varicocele which affects seminal parameters due to oxidative stress. For the first time, we aim to compare the efficacy of recombinant Human follicle stimulating hormone (rhFSH), Human chorionic gonadotropin (HCG) and Human Menopausal gonadotropin (HMG) on sperm parameters and fertility after varicocelectomy.Materials and Methods: 113 infertile men with varicocele were divided into four groups. Group A received HCG 5000 IU weekly, group B received HMG 75 IU three times a week, group C received rhFSH 75 IU three times a week and group D received no medical treatment after varicocelectomy. After three months treatment, group A illustrated improvement only in morphology (p=0.007) and pregnancy rate was reported to be 32%. In group B sperm motility (p=0.023) and morphology (p=0.014) improved which caused 57% of pregnancy rate. In group C all of the investigated conventional semen parameters increased (p<0.05) and pregnancy rate was 62.5%. Only Gonal-F improved sperm concentrations> 20x10 6 ⁄mL (p=0.027). In group D sperm morphology increased (p=0.038), but other parameters had no changes and no pregnancy occurred.Conclusion: It can be concluded that drugs can reduce the time of inducing spermatogenesis and fertility in comparison with varicocelectomy alone and rhFSH is more effective than other drugs.